Association between hyperkalemia, RAASi non-adherence and outcomes in chronic kidney disease.

ABSTRACT:

Background

Hyperkalemia is relatively frequent in CKD patients treated with renin-angiotensin-aldosterone-system inhibitors (RAASi).

Aim

The aim of the present study was to estimate the increased risk of cardiovascular events and mortality due to sub-optimal adherence to RAASi in CKD patients with hyperkalemia.

Methods

An observational retrospective cohort study was conducted, based on administrative and laboratory databases of five Local Health Units. Adult patients discharged from the hospital with a diagnosis of CKD, who were prescribed RAASi between January 2010 and December 2017, were included. We evaluated the appearance of documented episodes of hyperkalemia, RAASi therapy adherence and the effects of these two variables on cardiovascular events, death and dial

SUBMITTER: Santoro A 

PROVIDER: S-EPMC8927011 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature