Familial co-aggregation and shared heritability between depression, anxiety, obesity and substance use.

ABSTRACT: Depression, anxiety, obesity and substance use are heritable and often co-occur. However, the mechanisms underlying this co-occurrence are not fully understood. We estimated their familial aggregation and co-aggregation as well as heritabilities and genetic correlations to improve etiological understanding. Data came from the multi-generational population-based Lifelines Cohort Study (n = 162,439). Current depression and anxiety were determined using the MINI International Neuropsychiatric Interview. Smoking, alcohol and drug use were assessed by self-report questionnaires. Body mass index (BMI) and obesity were calculated by measured height and weight. Modified Cox proportional hazards models estimated recurrence risk ratios (λ_R), and restricted maximum likelihood variance deco

SUBMITTER: Wang R 

PROVIDER: S-EPMC8927111 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature