Oral antibiotic use and early-onset colorectal cancer: findings from a case-control study using a national clinical database.

ABSTRACT:

Background

Antibiotic-induced gut dysbiosis has been associated with colorectal cancer (CRC) in older adults. This study will investigate whether an association exists between antibiotic usage and early-onset colorectal cancer (CRC), and also evaluate this in later-onset CRC for comparison.

Methods

A case-control study was conducted using primary care data from 1999-2011. Analysis were conducted separately in early-onset CRC cases (diagnosed < 50 years) and later-onset cases (diagnosed ≥ 50 years). Conditional logistic regression was used to calculate odds ratios and 95% confidence intervals (CI) for the associations between antibiotic exposure and CRC by tumour location, adjusting for comorbidities.

Results

Seven thousands nine hundred and three CRC cases (445 aged <

SUBMITTER: McDowell R 

PROVIDER: S-EPMC8927122 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature