Thermally damaged porcine skin is not a surrogate mechanical model of human skin.

ABSTRACT: Porcine skin is considered a de facto surrogate for human skin. However, this study shows that the mechanical characteristics of full thickness burned human skin are different from those of porcine skin. The study relies on five mechanical properties obtained from uniaxial tensile tests at loading rates relevant to surgery: two parameters of the Veronda-Westmann hyperelastic material model, ultimate tensile stress, ultimate tensile strain, and toughness of the skin samples. Univariate statistical analyses show that human and porcine skin properties are dissimilar (p < 0.01) for each loading rate. Multivariate classification involving the five mechanical properties using logistic regression can successfully separate the two skin types with a classification accuracy exceeding 95% for each lo

SUBMITTER: Gallagher S 

PROVIDER: S-EPMC8927453 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature