CCDC134 as a Prognostic-Related Biomarker in Breast Cancer Correlating With Immune Infiltrates.

ABSTRACT:

Background

The expression of Coiled-Coil Domain Containing 134(CCDC134) is up-regulated in different pan-cancer species. However, its prognostic value and correlation with immune infiltration in breast cancer are unclear. Therefore, we evaluated the prognostic role of CCDC134 in breast cancer and its correlation with immune invasion.

Methods

We downloaded the transcription profile of CCDC134 between breast cancer and normal tissues from the Cancer Genome Atlas (TCGA). CCDC134 protein expression was assessed by the Clinical Proteomic Cancer Analysis Consortium (CPTAC) and the Human Protein Atlas. Gene set enrichment analysis (GSEA) was also used for pathway analysis. Receiver operating characteristic (ROC) curve was used to differentiate breast cancer from adjacent normal tis

SUBMITTER: Huang Z 

PROVIDER: S-EPMC8927640 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature