DNA Damage Repair-Related Genes Signature for Immune Infiltration and Outcome in Cervical Cancer.

ABSTRACT: Background: The mechanism of DNA damage repair plays an important role in many solid tumors represented by cervical cancer. Purpose: The purpose of this study was to explore the effect of DNA damage repair-related genes on immune function of patients with cervical cancer, and to establish and evaluate a prognosis model based on DNA damage repair-related genes. Methods: In the study, we analyzed the genes related to DNA damage and repair, and obtained two subtypes (F1 and F2). We selected two groups of samples for different selection, and studied which pathways were enriched expression. For different subtypes, the immune score was explored to explain immune infiltration. We got the key genes through screening, and established the prognosis model through the key genes. T

SUBMITTER: Wang X 

PROVIDER: S-EPMC8927729 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature