Evaluation of the Reproducibility and Robustness of Extrusion-Based Bioprinting Processes Applying a Flow Sensor.

ABSTRACT: Bioprinting is increasingly regarded as a suitable additive manufacturing method in biopharmaceutical process development and formulation. In order to manage the leap from research to industrial application, higher levels of reproducibility and a standardized bioprinting process are prerequisites. This said, the concept of process analytical technologies, standard in the biopharmaceutical industry, is still at its very early steps. To date most extrusion-based printing processes are controlled over penumatic pressure and thus not adaptive to environmental or system related changes over several experimental runs. A constant set pressure applied over a number of runs, might lead to variations in flow rate and thus to unreliable printed constructs. With this in mind, the simple question arise

SUBMITTER: Strauß S 

PROVIDER: S-EPMC8927775 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature