D-arginine Enhances the Effect of Alpha-Amylase on Disassembling Actinomyces viscosus Biofilm.

ABSTRACT: Peri-implantitis is the leading cause of dental implant failure, initially raised by biofilm accumulation on the implant surface. During the development of biofilm, Actinomyces viscosus (A. viscosus) plays a pivotal role in initial attachment as well as the bacterial coaggregation of multispecies pathogens. Hence, eliminating the A. viscosus-associated biofilm is fundamental for the regeneration of the lost bone around implants. Whereas clinical evidence indicated that antimicrobials and debridement did not show significant effects on the decontamination of biofilm on the implant surface. In this study, alpha-amylase was investigated for its effects on disassembling A. viscosus biofilm. Then, in order to substantially disperse biofilm under biosafety concentrati

SUBMITTER: Li B 

PROVIDER: S-EPMC8927782 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature