Bisphosphonates in Total Joint Arthroplasty: A Review of Their Use and Complications.

ABSTRACT:

Background

Considerable interest has been expressed in the use of bisphosphonates to treat periprosthetic osteoporosis with the clinical goals of reducing periprosthetic fractures and prolonging implant survival.

Methods

A systematic review was performed with the goal of identifying both basic science and clinical studies related to the risks and benefits of bisphosphonate use in total joint arthroplasty.

Results

Studies have shown that bisphosphonates may increase early bony ingrowth, decrease the postoperative loss of bone mineral density, and increase the longevity of implants by reducing the need for revisions secondary to aseptic loosening. Continuing bisphosphonates for 1 year postoperatively seems to provide the greatest benefit, with only marginal benefit bein

SUBMITTER: McDonald CL 

PROVIDER: S-EPMC8927797 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature