A genome-wide association study of outcome from traumatic brain injury.

ABSTRACT:

Background

Factors such as age, pre-injury health, and injury severity, account for less than 35% of outcome variability in traumatic brain injury (TBI). While some residual outcome variability may be attributable to genetic factors, published candidate gene association studies have often been underpowered and subject to publication bias.

Methods

We performed the first genome- and transcriptome-wide association studies (GWAS, TWAS) of genetic effects on outcome in TBI. The study population consisted of 5268 patients from prospective European and US studies, who attended hospital within 24 h of TBI, and satisfied local protocols for computed tomography.

Findings

The estimated heritability of TBI outcome was 0·26. GWAS revealed no genetic variants with genome-wide signi

SUBMITTER: Kals M 

PROVIDER: S-EPMC8927841 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature