Prognostic Value of Genomic Instability of m⁶A-Related lncRNAs in Lung Adenocarcinoma.

ABSTRACT: Background: Genomic instability of N6-methyladenosine (m⁶A)-related long noncoding RNAs (lncRNAs) plays a pivotal role in the tumorigenesis of lung adenocarcinoma (LUAD). Our study identified a signature of genomic instability of m⁶A-associated lncRNA signature and revealed its prognostic role in LUAD. Methods: We downloaded RNA-sequencing data and somatic mutation data for LUAD from The Cancer Genome Atlas (TCGA) and the GSE102287 dataset from the Gene Expression Omnibus (GEO) database. The "Limma" R package was used to identify a network of regulatory m⁶A-related lncRNAs. We used the Wilcoxon test method to identify genomic-instability-derived m⁶A-related lncRNAs. A competing endogenous RNA (ceRNA) network was constructed to ident

SUBMITTER: Li R 

PROVIDER: S-EPMC8928224 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature