The Infection of the Japanese Encephalitis Virus SA14-14-2 Strain Induces Lethal Peripheral Inflammatory Responses in IFNAR Deficiency Mice.

ABSTRACT: The Japanese encephalitis virus (JEV) is a leading cause of mosquito-borne viral encephalitis worldwide. Clinical symptoms other than encephalitis, on the other hand, are substantially more prevalent with JEV infection, demonstrating the relevance of peripheral pathophysiology. We studied the peripheral immunopathogenesis of JEV using IFNAR deficient (IFNAR^-/-) mice infected with the SA14-14-2 strain under the BSL-2. The body weight and survival rate of infected-IFNAR^-/-mice decreased significantly. Infected-IFNAR^-/-mice's liver and spleen demonstrated obvious tissue damage and inflammatory cell infiltration. There was also extensive viral replication in the organs. IFN-α/β protein expression was dramatically elevated in peripheral tissues and serum, althou

SUBMITTER: Liu J 

PROVIDER: S-EPMC8928384 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature