Biodegradable Protein-Stabilized Inorganic Nanoassemblies for Photothermal Radiotherapy of Hepatoma Cells.

ABSTRACT: Inorganic nanomaterials require optimal engineering to retain their functionality yet can also biodegrade within physiological conditions to avoid chronic accumulation in their native form. In this work, we have developed gelatin-stabilized iron oxide nanoclusters having a primary crystallite size of ∼10 nm and surface-functionalized with indocyanine green (ICG)-bound albumin-stabilized gold nanoclusters (Prot-IONs). The Prot-IONs are designed to undergo disintegration in an acidic microenvironment of tumor in the presence of proteolytic enzymes within 72 h. These nanoassemblies demonstrate bio- and hemocompatibility and show significant photothermal efficiency due to strong near infrared absorption contributed by ICG. The surface gold nanoclusters could efficiently sensitize hepatoma cell

SUBMITTER: Yadav P 

PROVIDER: S-EPMC8928496 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature