Disease activity, cytokines, chemokines and the risk of incident diabetes in rheumatoid arthritis.

ABSTRACT:

Purpose

Rheumatoid arthritis (RA) is associated with a higher risk of diabetes mellitus (DM). Our aim was to determine associations between inflammatory disease activity (including evaluation of specific cytokines and chemokines) and incident DM.

Methods

Participants were adults with physician-confirmed RA from Veteran's Affairs Rheumatoid Arthritis Registry. Disease activity and clinical assessments occur longitudinally as part of clinical care. Thirty cytokines and chemokines were measured in banked serum obtained at the time of enrolment. Cytokine/chemokine values were log-adjusted and standardised (per SD). Incident DM was defined based on validated algorithms using diagnostic codes and medications. Multivariable Cox proportional hazard models evaluated associations betw

SUBMITTER: Baker JF 

PROVIDER: S-EPMC8928597 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature