Breakthrough infections after COVID-19 vaccination: Insights, perspectives and challenges.

ABSTRACT: Vaccination programs against SARS-CoV-2 constitute the mainstay of public health interventions against the global COVID-19 pandemic. Currently available vaccines have shown 90% or better rates of protection against severe disease and mortality. Barely a year after vaccines became available, the Omicron variant and its unprecedented speed of transmission has posed a new challenge. Overall, Omicron presents increased immune escape, transmissibility, and decreased pathogenicity. Vaccines do not offer a full protection against SARS-CoV-2 acquisition, since "breakthrough" infections may occur in fully vaccinated individuals, who may in turn spread the virus to others. Breakthrough infections may be causally related to the viral profile (viral variant and load, incubation period, transmissibilit

SUBMITTER: Amanatidou E 

PROVIDER: S-EPMC8928742 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature