Early versus late intubation in COVID-19 patients failing helmet CPAP: A quantitative computed tomography study.

ABSTRACT:

Purpose

To describe the effects of timing of intubation in COVID-19 patients that fail helmet continuous positive airway pressure (h-CPAP) on progression and severity of disease.

Methods

COVID-19 patients that failed h-CPAP, required intubation, and underwent chest computed tomography (CT) at two levels of positive end-expiratory pressure (PEEP, 8 and 16 cmH₂O) were included in this retrospective study. Patients were divided in two groups (early versus late) based on the duration of h-CPAP before intubation. Endpoints included percentage of non-aerated lung tissue at PEEP of 8 cmH₂O, respiratory system compliance and oxygenation.

Results

Fifty-two patients were included and classified in early (h-CPAP for ≤2 days, N = 26) and late groups (h-CPAP

SUBMITTER: Ball L 

PROVIDER: S-EPMC8928743 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature