Interactome Analysis of KIN (Kin17) Shows New Functions of This Protein.

ABSTRACT: KIN (Kin17) protein is overexpressed in a number of cancerous cell lines, and is therefore considered a possible cancer biomarker. It is a well-conserved protein across eukaryotes and is ubiquitously expressed in all cell types studied, suggesting an important role in the maintenance of basic cellular function which is yet to be well determined. Early studies on KIN suggested that this nuclear protein plays a role in cellular mechanisms such as DNA replication and/or repair; however, its association with chromatin depends on its methylation state. In order to provide a better understanding of the cellular role of this protein, we investigated its interactome by proximity-dependent biotin identification coupled to mass spectrometry (BioID-MS), used for identification of protein-protein inte

SUBMITTER: Gaspar VP 

PROVIDER: S-EPMC8929021 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature