MC1R Is a Prognostic Marker and Its Expression Is Correlated with MSI in Colorectal Cancer.

ABSTRACT: Melanocortin 1 receptor (MC1R) is thought to be a marker of poor prognosis and a potential target for the treatment of melanoma. Studies have found that MC1R promotes several tumor behaviors, including cell proliferation and differentiation, pigment formation, and genome damage repair. Some single-nucleotide polymorphisms (SNPs) of MC1R are involved in the occurrence and development of melanoma. A few studies have reported a relationship between MC1R and colorectal cancer (CRC). In this research, our objective was to examine MC1R expression and MC1R SNPs and investigate their correlation with the clinicopathological features of human CRC tissues. We evaluated MC1R mRNA expression by performing bioinformatic analyses on human CRC expression d

SUBMITTER: Peng L 

PROVIDER: S-EPMC8929037 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature