Investigation of Antidepressant Properties of Yohimbine by Employing Structure-Based Computational Assessments.

ABSTRACT: The use of pharmaceuticals to treat Major Depressive Disorder (MDD) has several drawbacks, including severe side effects. Natural compounds with great efficacy and few side effects are in high demand due to the global rise in MDD and ineffective treatment. Yohimbine, a natural compound, has been used to treat various ailments, including neurological conditions, since ancient times. Serotonergic neurotransmission plays a crucial role in the pathogenesis of depression; thus, serotonergic receptor agonist/antagonistic drugs are promising anti-depressants. Yohimbine was investigated in this study to determine its antidepressant activity using molecular docking and pharmacokinetic analyses. Additionally, the in silico mutational study was carried out to understand the increase in therapeutic ef

SUBMITTER: Tasleem M 

PROVIDER: S-EPMC8929124 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature