Physiological, Pathological and Pharmacological Interactions of Hydrogen Sulphide and Nitric Oxide in the Myocardium of Rats with Left Ventricular Hypertrophy.

ABSTRACT: Left ventricular hypertrophy (LVH) is characterized by increased myocardium thickness due to increased oxidative stress and downregulation of cystathione γ lyase (CSE) endothelial nitric oxide synthase (eNOS). Upregulation of CSE by hydrogen sulphide (H₂S) and ENOS by L-arginine can arrest the progression of LVH individually. The present study explored the combined treatment of H₂S and NO in the progression of LVH, and demonstrated that the response is due to H₂S, NO or formation of either new molecule in physiological, pathological, and pharmacological in vivo settings of LVH. Exogenous administration H₂S+NO in LVH significantly reduced (all p < 0.05) systolic blood pressure (SBP) and mean arterial pressure (MAP), LV index, heart index

SUBMITTER: Ahmad A 

PROVIDER: S-EPMC8929131 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature