The interacting physiology of COVID-19 and the renin-angiotensin-aldosterone system: Key agents for treatment.

ABSTRACT: SARS-CoV-2 interacting with its receptor, angiotensin-converting enzyme 2 (ACE2), turns the host response to viral infection into a dysregulated uncontrolled inflammatory response. This is because ACE2 limits the production of the peptide angiotensin II (Ang II) and SARS-CoV-2, through the destruction of ACE2, allows the uncontrolled production of Ang II. Recovery from trauma requires activation of both a tissue response to injury and activation of a whole-body response to maintain tissue perfusion. Tissue and circulating renin-angiotensin systems (RASs) play an essential role in the host response to infection and injury because of the actions of Ang II, mediated via its AT₁ receptor. Both tissue and circulating arms of the renin angiotensin aldosterone system's (RAAS) response

SUBMITTER: Lumbers ER 

PROVIDER: S-EPMC8929333 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature