Pathway analysis of smoking-induced changes in buccal mucosal gene expression.

ABSTRACT:

Background

Cigarette smoking is the leading preventable cause of death worldwide, and it is the most common cause of oral cancers. This study aims to provide a deeper understanding of the molecular pathways in the oral cavity that are altered by exposure to cigarette smoke.

Methods

The gene expression dataset (accession number GSE8987, GPL96) of buccal mucosa samples from smokers (n = 5) and never smokers (n = 5) was downloaded from The National Center for Biotechnology Information's (NCBI) Gene Expression Omnibus (GEO) repository. Differential expression was ascertained via NCBI's GEO2R software, and Ingenuity Pathway Analysis (IPA) software was used to perform a pathway analysis.

Results

A total of 459 genes were found to be significantly differentiall

SUBMITTER: Khaleel A 

PROVIDER: S-EPMC8929449 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature