Association between lithium use and the incidence of dementia and its subtypes: A retrospective cohort study.

ABSTRACT:

Background

Dementia is the leading cause of death in elderly Western populations. Preventative interventions that could delay dementia onset even modestly would provide a major public health impact. There are no disease-modifying treatments currently available. Lithium has been proposed as a potential treatment. We assessed the association between lithium use and the incidence of dementia and its subtypes.

Methods and findings

We conducted a retrospective cohort study comparing patients treated between January 1, 2005 and December 31, 2019, using data from electronic clinical records of secondary care mental health (MH) services in Cambridgeshire and Peterborough NHS Foundation Trust (CPFT), United Kingdom (catchment area population approximately 0.86 million). Eligible pati

SUBMITTER: Chen S 

PROVIDER: S-EPMC8929585 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature