C-D-index at day 11 can predict febrile neutropenia during chemotherapy in acute myeloid leukemia.

ABSTRACT: Acute myeloid leukemia (AML) often requires long-term intensive chemotherapy for its cure. During chemotherapy, the patient always experiences neutropenia with readings below 500 cells/μL; this is often accompanied by pyrexia with a temperature of more than 101°F. This combination of neutropenia and fever is called febrile neutropenia (FN). A tool to sum up the daily severity of a patient's neutropenia, the "D-index," has been validated in some specific clinical settings. In this study, we examined whether the D-index is a useful predictor of the onset of FN. We recruited consecutive patients treated with induction and consolidation chemotherapy for newly diagnosed AML. We gathered all the FN events and their clinical background data retrospectively. Patients' background, such as pre-exist

SUBMITTER: Kubo H 

PROVIDER: S-EPMC8929597 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature