Preoperative Status of Gut Microbiota Predicts Postoperative Delirium in Patients With Gastric Cancer.

ABSTRACT:

Introduction

Post-operative delirium (POD) is a serious complication which occurs after surgery, especially in the elderly undergoing abdominal surgery. Increasing evidence has revealed an association between the gut microbiota and psychological disorders involving the "brain-gut" axis. However, the association between the pathogenesis of POD after abdominal surgery in aging and composition of the gut microbiota remains unclear.

Methods

Forty patients (≥65 years old) who underwent abdominal surgery were included in the study. Twenty patients had POD, whereas 20 patients did not. POD was diagnosed and assessed using the confusion assessment method (CAM) during the postoperative period. Total DNA fractions were extracted from all fecal samples of patients. 16S rRNA sequencing

SUBMITTER: Liu H 

PROVIDER: S-EPMC8929925 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature