Optimising respiratory support for early COVID-19 pneumonia: a computational modelling study.

ABSTRACT:

Background

Optimal respiratory support in early COVID-19 pneumonia is controversial and remains unclear. Using computational modelling, we examined whether lung injury might be exacerbated in early COVID-19 by assessing the impact of conventional oxygen therapy (COT), high-flow nasal oxygen therapy (HFNOT), continuous positive airway pressure (CPAP), and noninvasive ventilation (NIV).

Methods

Using an established multi-compartmental cardiopulmonary simulator, we first modelled COT at a fixed FiO₂ (0.6) with elevated respiratory effort for 30 min in 120 spontaneously breathing patients, before initiating HFNOT, CPAP, or NIV. Respiratory effort was then reduced progressively over 30-min intervals. Oxygenation, respiratory effort, and lung stress/strain were quantifi

SUBMITTER: Weaver L 

PROVIDER: S-EPMC8930396 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature