Chemical exposures assessed via silicone wristbands and endogenous plasma metabolomics during pregnancy.

ABSTRACT:

Background

Metabolomics is a promising method to investigate physiological effects of chemical exposures during pregnancy, with the potential to clarify toxicological mechanisms, suggest sensitive endpoints, and identify novel biomarkers of exposures.

Objective

Investigate the influence of chemical exposures on the maternal plasma metabolome during pregnancy.

Methods

Data were obtained from participants (n = 177) in the New Hampshire Birth Cohort Study, a prospective pregnancy cohort. Chemical exposures were assessed via silicone wristbands worn for one week at ~13 gestational weeks. Metabolomic features were assessed in plasma samples obtained at ~24-28 gestational weeks via the Biocrates AbsoluteIDQ® p180 kit and nuclear magnetic resonance (NMR) spectroscopy. Associ

SUBMITTER: Doherty BT 

PROVIDER: S-EPMC8930423 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature