MiR-205-5p promotes lung cancer progression and is valuable for the diagnosis of lung cancer.

ABSTRACT:

Background

MicroRNAs (miRNAs) function as potential diagnostic biomarkers in various cancers. This study aimed to evaluate the roles of miR-205-5p in lung cancer progression and diagnosis.

Materials and methods

MiR-205-5p was detected by quantitative real-time PCR. The effect of miR-205-5p on cell proliferation and metastasis was estimated by MTT and flow cytometry. The expression of TP53INP1 and related genes was analyzed by immunoblotting. The diagnostic value of miR-205-5p was analyzed using receiver operating characteristic (ROC) curve analysis, sensitivity, and specificity.

Results

The miR-205-5p was increased in lung cancer tissues. MiR-205-5p mimics were promoted but its inhibitor suppressed cell proliferation and metastasis compared with control treatment in v

SUBMITTER: Zhao YL 

PROVIDER: S-EPMC8930496 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature