Gut microbiome features associated with liver fibrosis in Hispanics, a population at high risk for fatty liver disease.

ABSTRACT:

Background and aims

Hispanics are disproportionately affected by NAFLD, liver fibrosis, cirrhosis, and HCC. Preventive strategies and noninvasive means to identify those in this population at high risk for liver fibrosis, are urgently needed. We aimed to characterize the gut microbiome signatures and related biological functions associated with liver fibrosis in Hispanics and identify environmental and genetic factors affecting them.

Approach and results

Subjects of the population-based Cameron County Hispanic Cohort (CCHC; n = 217) were screened by vibration-controlled transient elastography (FibroScan). Among them, 144 (66.7%) had steatosis and 28 (13.0%) had liver fibrosis. The gut microbiome of subjects with liver fibrosis was enriched with immunogenic commensals (e.g.,

SUBMITTER: Kwan SY 

PROVIDER: S-EPMC8930512 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature