Plasma Metabolites Associated with a Protein-Rich Dietary Pattern: Results from the OmniHeart Trial.

ABSTRACT:

Scope

Lack of biomarkers is a challenge for the accurate assessment of protein intake and interpretation of observational study data. The study aims to identify biomarkers of a protein-rich dietary pattern.

Methods and results

The Optimal Macronutrient Intake Trial to Prevent Heart Disease (OmniHeart) trial is a randomized cross-over feeding study which tested three dietary patterns with varied macronutrient content (carbohydrate-rich; protein-rich with about half from plant sources; and unsaturated fat-rich). In 156 adults, differences in log-transformed plasma metabolite levels at the end of the protein- and carbohydrate-rich diet periods using paired t-tests is examined. Partial least-squares discriminant analysis is used to identify a set of metabolites which are influen

SUBMITTER: Kim H 

PROVIDER: S-EPMC8930517 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature