Flexible encoding of objects and space in single cells of the dentate gyrus.

ABSTRACT: The hippocampus is involved in the formation of memories that require associations among stimuli to construct representations of space and the items and events within that space. Neurons in the dentate gyrus (DG), an initial input region of the hippocampus, have robust spatial tuning, but it is unclear how nonspatial information may be integrated with spatial activity in this region. We recorded from the DG of 21 adult mice as they foraged for food in an environment that contained discrete objects. We found DG cells with multiple firing fields at a fixed distance and direction from objects (landmark vector cells) and cells that exhibited localized changes in spatial firing when objects in the environment were manipulated. By classifying recorded DG cells into putative dentate granule cells

SUBMITTER: GoodSmith D 

PROVIDER: S-EPMC8930604 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature