Surfactant Therapy for Respiratory Distress Syndrome in High- and Ultra-High-Altitude Settings.

ABSTRACT:

Objective

The objective of this study is to investigate the therapeutic effect of surfactant replacement therapy (SRT) on respiratory distress syndrome (RDS) in premature infants in the Qinghai-Tibet Plateau.

Materials and methods

This multi-center retrospective cohort study collected and screened reasonable clinical data of 337 premature infants with RDS from 10 hospitals in the Qinghai-Tibet Plateau from 2015 to 2017. We grouped the cases by rationally analyzing their baseline characteristics, using logistic analysis to evaluate each factor's effect on the prognosis of the infants, and comparing the short-term improvement in blood gas and mortality after SRT treatment at different altitudes, in high-altitude (1,500-3,500 m) and ultra-high-altitude (3,500-5,500 m) groups.

SUBMITTER: Duan X 

PROVIDER: S-EPMC8930851 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature