Microglia and Stem-Cell Mediated Neuroprotection after Neonatal Hypoxia-Ischemia.

ABSTRACT: Neonatal hypoxia-ischemia encephalopathy (HIE) refers to a brain injury in term infants that can lead to death or lifelong neurological deficits such as cerebral palsy (CP). The pathogenesis of this disease involves multiple cellular and molecular events, notably a neuroinflammatory response driven partly by microglia, the brain resident macrophages. Treatment options are currently very limited, but stem cell (SC) therapy holds promise, as beneficial outcomes are reported in animal studies and to a lesser degree in human trials. Among putative mechanisms of action, immunomodulation is considered a major contributor to SC associated benefits. The goal of this review is to examine whether microglia is a cellular target of SC-mediated immunomodulation and whether the recruitment of microglia

SUBMITTER: Bregere C 

PROVIDER: S-EPMC8930888 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature