Does temporal irregularity drive prediction failure in schizophrenia? temporal modelling of ERPs.

ABSTRACT: Schizophrenia subjects often suffer from a failure to properly predict incoming inputs; most notably, some patients exhibit impaired prediction of the sensory consequences of their own actions. The mechanisms underlying this deficit remain unclear, though. One possible mechanism could consist in aberrant predictive processing, as schizophrenic patients show relatively less attenuated neuronal activity to self-produced tones, than healthy controls. Here, we tested the hypothesis that this aberrant predictive mechanism would manifest itself in the temporal irregularity of neuronal signals. For that purpose, we here introduce an event-related potential (ERP) study model analysis that consists of an EEG real-time model equation, eeg(t) and a frequency Laplace transformed Transfer Function (TF)

SUBMITTER: Karanikolaou M 

PROVIDER: S-EPMC8931057 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature