Goal discrimination in hippocampal nonplace cells when place information is ambiguous.

ABSTRACT: SignificanceGoal-directed spatial navigation has been found to rely on hippocampal neurons that are spatially modulated. We show that "nonplace" cells without significant spatial modulation play a role in discriminating goals when environmental cues for goals are ambiguous. This nonplace cell activity is performance-dependent and is modulated by gamma oscillations. Finally, nonplace cell goal discrimination coding fails in a mouse model of Alzheimer's disease (AD). Together, these results show that nonplace cell firing can signal unique task-relevant information when spatial information is ambiguous; these signals depend on performance and are absent in a mouse model of AD.

SUBMITTER: Zhang L 

PROVIDER: S-EPMC8931233 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature