Recurrent Severe Subclinical Mastitis and the Risk of HIV Transmission Through Breastfeeding.

ABSTRACT: Subclinical mastitis (SCM) is an important risk factor of postnatal HIV-1 transmission that is still poorly understood. A longitudinal sub-study of the ANRS12174 trial including 270 breastfeeding mothers in Lusaka, Zambia measured sodium (Na⁺) and potassium (K⁺) in archived paired breast milk samples collected at week 14, 26 and 38 postpartum to determine cumulative incidence of SCM and the effects of recurrent severe SCM on HIV-1 shedding in breast milk. A nested retrospective cohort study including 112 mothers was also done to determine longitudinal effects of SCM on four pro-inflammatory cytokines; IL6, IL8, IP10 and RANTES. The cumulative incidence for any SCM (Na ⁺ /K ⁺ ratio > 0.6) and severe SCM (Na ⁺ /K

SUBMITTER: Rutagwera DG 

PROVIDER: S-EPMC8931278 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature