Inhibitors of PARP: Number crunching and structure gazing.

ABSTRACT: SignificancePARP is an important target in the treatment of cancers, particularly in patients with breast, ovarian, or prostate cancer that have compromised homologous recombination repair (i.e., BRCA^-/-). This review about inhibitors of PARP (PARPi) is for readers interested in the development of next-generation drugs for the treatment of cancer, providing insights into structure-activity relationships, in vitro vs. in vivo potency, PARP trapping, and synthetic lethality.

SUBMITTER: Rudolph J 

PROVIDER: S-EPMC8931346 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature