Zafirlukast inhibits the growth of lung adenocarcinoma via inhibiting TMEM16A channel activity.

ABSTRACT: Lung cancer has the highest mortality among cancers worldwide due to its high incidence and lack of the effective cures. We have previously demonstrated that the membrane ion channel TMEM16A is a potential drug target for the treatment of lung adenocarcinoma and have identified a pocket of inhibitor binding that provides the basis for screening promising new inhibitors. However, conventional drug discovery strategies are lengthy and costly, and the unpredictable side effects lead to a high failure rate in drug development. Therefore, finding new therapeutic directions for already marketed drugs may be a feasible strategy to obtain safe and effective therapeutic drugs. Here, we screened a library of over 1400 Food and Drug Administration-approved drugs through virtual screening and activity

SUBMITTER: Shi S 

PROVIDER: S-EPMC8931426 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature