Antibodies binding diverse pertactin epitopes protect mice from Bordetella pertussis infection.

ABSTRACT: Infection by the bacterium Bordetella pertussis continues to cause considerable morbidity and mortality worldwide. Many current acellular pertussis vaccines include the antigen pertactin, which has presumptive adhesive and immunomodulatory activities, but is rapidly lost from clinical isolates after the introduction of these vaccines. To better understand the contributions of pertactin antibodies to protection and pertactin's role in pathogenesis, we isolated and characterized recombinant antibodies binding four distinct epitopes on pertactin. We demonstrate that four of these antibodies bind epitopes that are conserved across all three classical Bordetella strains, and competition assays further showed that antibodies binding these epitopes are also elicited by B. pertussis infection of b

SUBMITTER: Silva RP 

PROVIDER: S-EPMC8931430 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature