Impact of adjuvant imatinib on bone and muscle density in patients with resected gastrointestinal stromal tumors.

ABSTRACT: Adjuvant treatment with Imatinib is the standard of care for high-risk resected GISTs. Imatinib is known to have an impact on bone mineral density in patients affected by chronic myeloid leukemia, however this effect has never been investigated in GISTs. We retrospectively evaluated, on CT scans, the effect of adjuvant Imatinib (400 mg/die) on bone mineral density and muscle composition in 14 patients with surgically resected GISTs and in a control group of 8 patients who did not received any treatment. The effect of bone and muscle composition on Imatinib-tolerance was assessed as well. Overall patients receiving Imatinib experienced an increase in bone mineral density during treatment (p = 0.021); with higher increase in patients with basal values < 120 mg/cm³ (p = 0.002). No

SUBMITTER: Fulgenzi CAM 

PROVIDER: S-EPMC8931443 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature