Derivation and Validation of the Cognitive Impairment Prediction Model in Older Adults: A National Cohort Study.

ABSTRACT:

Objective

This prediction model quantifies the risk of cognitive impairment. This aim of this study was to develop and validate a prediction model to calculate the 6-year risk of cognitive impairment.

Methods

Participants from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) 2008-2014 and 2011-2018 surveys were included for developing the cognitive impairment prediction model. The least absolute shrinkage and selection operator, clinical knowledge, and previous experience were performed to select predictors. The Cox proportional hazard model and Fine-Gray analysis adjusting for death were conducted to construct the model. The discriminative ability was measured using C-statistics. The model was evaluated externally using the temporal validation method via the

SUBMITTER: Hu M 

PROVIDER: S-EPMC8931520 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature