Circulation of genotypes of dengue virus serotype 2 in Guangzhou over a period of 20 years.

ABSTRACT:

Background

The dengue epidemic in Guangzhou has imposed a rising burden on society and health infrastructure. Here, we present the genotype data for dengue virus serotype 2 (DENV-2) to improve understanding of this dengue epidemic.

Methods

We sequenced the envelope gene of DENV-2 obtained from patient serum samples and subsequently performed maximum-likelihood phylogenetic analysis using PhyMLv3.1, maximum clade credibility analysis using BEAST v.1.10.4, and selection pressure analysis using Datamonkey 2.0.

Results

The prevalent DENV-2 strains identified in Guangzhou region are related to those in Southeast Asian countries. In particular, the Malaysia/Indian subcontinent genotype is prevailing in Guangzhou with no apparent genotype shift having occurred over the past

SUBMITTER: Jiang L 

PROVIDER: S-EPMC8931567 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature