Dataset Information

The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19.

ABSTRACT:

Purpose

Critically ill old intensive care unit (ICU) patients suffering from Sars-CoV-2 disease (COVID-19) are at increased risk for adverse outcomes. This post hoc analysis investigates the association of the Activities of Daily Living (ADL) with the outcome in this vulnerable patient group.

Methods

The COVIP study is a prospective international observational study that recruited ICU patients ≥ 70 years admitted with COVID-19 (NCT04321265). Several parameters including ADL (ADL; 0 = disability, 6 = no disability), Clinical Frailty Scale (CFS), SOFA score, intensive care treatment, ICU- and 3-month survival were recorded. A mixed-effects Weibull proportional hazard regression analyses for 3-month mortality adjusted for multiple confounders.

Results

This pre-specified analysis included 2359 patients with a documented ADL and CFS. Most patients evidenced independence in their daily living before hospital admission (80% with ADL = 6). Patients with no frailty and no disability showed the lowest, patients with frailty (CFS ≥ 5) and disability (ADL < 6) the highest 3-month mortality (52 vs. 78%, p < 0.001). ADL was independently associated with 3-month mortality (ADL as a continuous variable: aHR 0.88 (95% CI 0.82-0.94, p < 0.001). Being "disable" resulted in a significant increased risk for 3-month mortality (aHR 1.53 (95% CI 1.19-1.97, p 0.001) even after adjustment for multiple confounders.

Conclusion

Baseline Activities of Daily Living (ADL) on admission provides additional information for outcome prediction, although most critically ill old intensive care patients suffering from COVID-19 had no restriction in their ADL prior to ICU admission. Combining frailty and disability identifies a subgroup with particularly high mortality.

Trial registration number

NCT04321265.

SUBMITTER: Bruno RR

PROVIDER: S-EPMC8931579 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Publications

The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19.

Bruno Raphael Romano RR Wernly Bernhard B Flaatten Hans H Fjølner Jesper J Artigas Antonio A Baldia Philipp Heinrich PH Binneboessel Stephan S Bollen Pinto Bernardo B Schefold Joerg C JC Wolff Georg G Kelm Malte M Beil Michael M Sviri Sigal S van Heerden Peter Vernon PV Szczeklik Wojciech W Elhadi Muhammed M Joannidis Michael M Oeyen Sandra S Kondili Eumorfia E Marsh Brian B Wollborn Jakob J Andersen Finn H FH Moreno Rui R Leaver Susannah S Boumendil Ariane A De Lange Dylan W DW Guidet Bertrand B Jung Christian C

Annals of intensive care 20220318 1

<h4>Purpose</h4>Critically ill old intensive care unit (ICU) patients suffering from Sars-CoV-2 disease (COVID-19) are at increased risk for adverse outcomes. This post hoc analysis investigates the association of the Activities of Daily Living (ADL) with the outcome in this vulnerable patient group.<h4>Methods</h4>The COVIP study is a prospective international observational study that recruited ICU patients ≥ 70 years admitted with COVID-19 (NCT04321265). Several parameters including ADL (ADL; ...[more]

PMID: 35303201

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Dataset Information

The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19.

Purpose

Methods

Results

Conclusion

Trial registration number

Publications

The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19.

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