Abnormal Changes of Monocyte Subsets in Patients With Sjogren's Syndrome.

ABSTRACT:

Background

Recent studies have proven the existence of distinct monocyte subsets, which play a significant role in the development of some rheumatic diseases such as systemic lupus erythematosus (SLE). This study was performed to define the changes of monocyte subsets in patients with Sjögren's Syndrome (SjS).

Methods

Single cell RNA-sequencing (scRNA-seq) data of monocytes from SjS patients and controls were analyzed. The transcriptomic changes in monocyte subsets between SjS and controls were identified and potential key functional pathways involved in SjS development were also explored.

Results

A total of 11 monocyte subsets were identified in the scRNA-seq analyses of monocytes. A new monocyte subset characterized by higher expression of VNN2 (GPI-80) and S100A12

SUBMITTER: He Y 

PROVIDER: S-EPMC8931697 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature