PET Imaging of Small Extracellular Vesicles via [⁸⁹Zr]Zr(oxinate)₄ Direct Radiolabeling.

ABSTRACT: Exosomes or small extracellular vesicles (sEVs) are increasingly gaining attention for their potential as drug delivery systems and biomarkers of disease. Therefore, it is important to understand their in vivo biodistribution using imaging techniques that allow tracking over time and at the whole-body level. Positron emission tomography (PET) allows short- and long-term whole-body tracking of radiolabeled compounds in both animals and humans and with excellent quantification properties compared to other nuclear imaging techniques. In this report, we explored the use of [⁸⁹Zr]Zr(oxinate)₄ (a cell and liposome radiotracer) for direct and intraluminal radiolabeling of several types of sEVs, achieving high radiolabeling yields. The radiosynthesis and radiolabeling

SUBMITTER: Khan AA 

PROVIDER: S-EPMC8931726 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature