Three-Component Coupling of Arenes, Ethylene, and Alkynes Catalyzed by a Cationic Bis(phosphine) Cobalt Complex: Intercepting Metallacyclopentenes for C-H Functionalization.

ABSTRACT: A cobalt-catalyzed intermolecular three-component coupling of arenes, ethylene, and alkynes was developed using the well-defined air-stable cationic bis(phosphine) cobalt(I) complex, [(dcype)Co(η⁶-C₇H₈)][BAr^F₄] (dcype = 1,2-bis(dicyclohexylphosphino)ethane; BAr^F₄ = B[(3,5-(CF₃)₂)C₆H₃]₄), as the precatalyst. All three components were required for turnover and formation of ortho-homoallylated arene products. A range of directing groups including amide, ketone, and 2-pyridyl substituents on the arene promoted the reaction. The cobalt-catalyzed method exhibited broad functional group tolerance allowing for the late-stage functionalization of two drug molecu

SUBMITTER: Whitehurst WG 

PROVIDER: S-EPMC8931730 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature