Glycoprotein hormone α-subunit promotes cell proliferation and tumorigenesis in breast cancer.

ABSTRACT: The glycoprotein hormone α-subunit (CGA) is implicated in the occurrence and progression of a number of solid tumors. However, its role in breast cancer remains unclear. The present study aimed to investigate the biological functions and mechanisms of action of CGA in breast cancer. CGA protein expression was evaluated in clinical breast cancer specimens using immunohistochemistry. The association between CGA expression and patient prognosis was determined using the Kaplan-Meier method and Mantel-Cox test. At the same time, CGA mRNA and protein expression was explored in a normal mammary epithelial cell line and breast cancer cell lines. Breast cancer cell lines overexpressing or deficient in CGA were established, and the effect of CGA on cell proliferation was evaluated in vitro, a

SUBMITTER: Zhou J 

PROVIDER: S-EPMC8931806 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature