Yin Yang 1 regulates ITGAV and ITGB1, contributing to improved prognosis of colorectal cancer.

ABSTRACT: Yin Yang 1 (YY1) is a multifunctional transcription factor with critical roles in carcinogenesis and metastasis. However, its biological role and clinical impact in colorectal cancer (CRC) remain unclear. In the present study, the function and underlying molecular mechanisms of YY1 in CRC progression were investigated. The immunohistochemistry (IHC) of 143 CRC tissues revealed a significant correlation of low YY1 expression with aggressive clinicopathological features, increased metastasis and recurrence and poor patient survival. Multivariate analysis identified low YY1 expression as an independent poor prognostic factor. Subsequently, the IHC of 66 paired CRC primary tumor and liver metastasis tissues revealed that low YY1 expression in the primary CRC was significantly associated with m

SUBMITTER: Sato N 

PROVIDER: S-EPMC8931837 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature