Integrative analysis identifies key genes related to metastasis and a robust gene-based prognostic signature in uveal melanoma.

ABSTRACT:

Purpose

Uveal melanoma (UM) is an aggressive intraocular malignancy, leading to systemic metastasis in half of the patients. However, the mechanism of the high metastatic rate remains unclear. This study aimed to identify key genes related to metastasis and construct a gene-based signature for better prognosis prediction of UM patients.

Methods

Weighted gene co-expression network analysis (WGCNA) was used to identify the co-expression of genes primarily associated with metastasis of UM. Univariate, Lasso-penalized and multivariate Cox regression analyses were performed to establish a prognostic signature for UM patients.

Results

The tan and greenyellow modules were significantly associated with the metastasis of UM patients. Significant genes related to the overall su

SUBMITTER: Lei S 

PROVIDER: S-EPMC8932077 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature