Impact of polygenic risk for coronary artery disease and cardiovascular medication burden on cognitive impairment in psychotic disorders.

ABSTRACT:

Background

Cognitive impairment is a core deficit across psychotic disorders, the causes and therapeutics of which remain unclear. Epidemiological observations have suggested associations between cognitive dysfunction in psychotic disorders and cardiovascular risk factors, but an underlying etiology has not been established.

Methods

Neuropsychological performance using the Brief Assessment of Cognition in Schizophrenia (BACS) was assessed in 616 individuals of European ancestry (403 psychosis, 213 controls). Polygenic risk scores for coronary artery disease (PRS_CAD) were quantified for each participant across 13 p-value thresholds (P_T 0.5-5e^-8). Cardiovascular and psychotropic medications were categorized for association analyses. Each PRS

SUBMITTER: Zhang L 

PROVIDER: S-EPMC8932335 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature